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STRUCTURAL BIOLOGY

PROTEINS

  • Modeling of multidomain and multimeric proteins

  • Protein-protein, protein-DNA, protein-ligand interactions

  • IDPs (Intrinsically Disordered Proteins)

  • Protein structure determination

  • Protein dynamics

  • Protein resonance assignments

  • pKa determination of active-site residues

  • Advice on construct design, expression of labeled proteins, protein purification

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Biophysical Studies

SAXS: Shapes of proteins, useful to model multidomain and multimeric proteins*

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AUC: Multimeric states under different conditions#

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ITC: Dissociation/association constants of homodimers, heterodimers, protein-ligand complexes#

*SAXS data will be collected at SLAC (Stanford Linear Accelerator Center

#AUC and ITC data will be collected at University of Washington, Seattle.

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